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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Ajit Yoganathan, PhD, - faculty host
Summary Sentence: "The Coulter Principle" - Don Graham, PhD
Full Summary: The Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.
Graham, Don
Bioengineering Seminar Series"The Coulter Principle"
Don Graham, PhD
The Wallace H. Coulter Department of Biomedical Engineering exists because of an elegant principle that is simply expressed: a cell or particle, suspended in an electrolyte and passed through a suitable constriction in which an electric current is also flowing, produces a detectable change in the current. But its apparent simplicity proves deceptive if this Coulter Principle is to be implemented in a practical instrument. The sensing structure is an electrochemical cell divided into two insulated compartments, and the sensing constriction is typically a short conduit, or Coulter aperture, connecting the two compartments through which the sample suspension and electrical current simultaneously flow. The hydrodynamic and electric fields in and near the aperture are complex, and their effects on electrical pulses generated by particles transiting the aperture must be recognized if the full potential of the Principle is to be realized. The history and practical implementation of the Coulter Principle will be outlined.
