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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Paloma Giangrande, University of Iowa
TIGRs: Targeted image-guided RNA therapies
Biochemistry Division Seminar Series
Dr. Giangrande 's research interests include developing RNA-based therapeutics to modulate cellular pathways underlying pathological cell proliferation in the setting of cancer and cardiovascular disease. One area of Dr. Giangrande’s lab focuses on selecting RNA aptamers to receptors expressed on the surface of target-cells with SELEX (Systemic Evolution of Ligands by EXponential Enrichment) for the purpose of 1) modulating receptor function and/or 2) delivering therapeutic molecules (e.g. siRNAs, antagomirs, drugs) into specific cell types. A second interest of the Giangrande lab is to use genomic/proteomic methodologies to acquire important insights into the mechanisms of pathological cell proliferation. In addition to providing useful mechanistic information, this knowledge will be used to identify novel membrane proteins that can be targeted with therapeutic RNAs for treating cancer or pathological vascular hyperplasia.
For more information contact Prof. M. G. Finn (404-894-0591)
